Endocrine Abstracts

Diabetes mellitus (DM) type MODY (Maturity Onset Diabetes of the Young) accounts 10% of cases of diabetes with onset before 35 years. The aim was to determine characteristics of the course of the main types of MODY.Materials and Methods: 45 patients aged 18 to 35 years diagnosed with MODY molecular genetic testing (next-generation sequencing technology and direct automated Sanger sequencing) were included: 31 had mutations in the GCK gene, 14 - ...

The age group under 45 years is the most difficult to determine the type of diabetes mellitus (DM), it can include type 1 (DM1), type 2 (DM2), MODY and LADA diabetes. Objective of the study: to determine clinical markers for differential diagnosis of types of DM in young patients.Materials and Methods: 202 patients with onset of diabetes aged 18 to 45 years were included: group 1 - 77 patients with MODY, 2 - 83 with DM 2, 3 - 14 with DM 1, 4 - 28 with LA...

Objective: To evaluate the chance of developing new cases of Type 2 diabetes mellitus (DM) in obese people in the population sample of the city of Novosibirsk aged 45–69 years.Materials and methods: The analysis included 2464 people, including 586 (23.7%) men and 1878 (76.2%) women without DM. This sample was formed from the base of the international project HAPIEE surveyed from 2003 to 2005. When conducting a re-screening of the same sample in 2006...

Most young patients with hyperglycemia are diagnosed with type 1 diabetes mellitus and type 2 diabetes mellitus (T2DM) but up to 10% of all cases of the disease occur in MODY diabetes. Diagnosis of the correct type of diabetes mellitus (DM) leads to the appointment of pathogenetic effective therapy, adequate management of pregnancy and the prevention of specific complications. The aim of the study was to create a model for the differential diagnosis of T2DM and MODY.<p cla...

Hyperglycemia in a 27–year–old woman without obesity was found in the first trimester of her third pregnancy in 2015 (fasting plasma glucose – 5.8 mmol /l). Gestational diabetes was established and insulin was initiated in basal–bolus regimen. After delivery the blood glucose was normal due two months then hyperglycemia increased to 15 mmol/l. Metformin and glimepiride were prescribed within effect. Then insulin detemir (8 U/day) was prescribed with DPP...

We previously have reported that short-term treatment of mice with recombinant hGH leads to significant increases in bodyweight (BW), lean body mass (LBM) and liver weight, but – unlike in humans – does not robustly increase circulating levels of IGF1. We now tested the hypothesis that formation of neutralizing antibodies in mice treated with rhGH could explain the lack of IGF1 response. Therefore, we intentionally induced antibody formation against hGH in female FVB...